PDFAmes, B. N. and Gold, L.S. Paracelsus to Parascience: The Environmental Cancer Distraction. Mutation Research 447, 3-13 (2000). PDF
Entering a new millennium seems a good time to challenge some old ideas, which in our view are implausible, have little supportive evidence, and might best be left behind. In this essay we summarize a decade of work, raising four issues that involve toxicology, nutrition, public health, and government regulatory policy. a) Paracelsus or parascience: the dose (trace) makes the poison. Half of all chemicals, whether natural or synthetic, are positive in high-dose rodent cancer tests. These results are unlikely to be relevant at the low doses of human exposure. b) Even Rachel Carson was made of chemicals: natural vs. synthetic chemicals. Human exposure to naturally-occurring rodent carcinogens is ubiquitous, and dwarfs exposure of the general public to synthetic rodent carcinogens. c) Errors of omission: micronutrient inadequacy is genotoxic. The major causes of cancer (other than smoking) do not involve exogenous carcinogenic chemicals: dietary imbalances, hormonal factors, infection and inflammation, and genetic factors. Insufficiency of many micronutrients, which appears to mimic radiation, is a preventable source of DNA damage. d) Damage by distraction: regulating low hypothetical risks. Putting huge amounts of money into minuscule hypothetical risks damages public health by diverting resources and distracting the public from major risks.
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Last updated: August 6, 2007