The Carcinogenic Potency Project

Bis(2,3-dibromopropyl)phosphate, magnesium salt (CAS 36711-31-6)
SMILES, InChI and Structure are below.
Rats and Mice: Cancer Test Summary
Rat Target Sites Mouse Target Sites TD50 (mg/kg/day)
Male Female Male Female Rat Mouse
eso smi sto eso liv smi sto no test no test 32m no test

Key to the Table Above

Positivity: For each chemical with a positive (carcinogenic) experiment in the Carcinogenic Potency Database (CPDB), results are included on carcinogenic potency (TD50) in each species and target sites in males and females. Positivity is determined by an author’s opinion in a published paper. If all experimental results in the CDPB are negative in a sex-species group, “no positive” appears. If the CPDB has no experiments in the sex-species group, “no test” appears. The summary presents the strongest evidence of carcinogenicity in each group. If there are both positive and negative experiments in a sex-species, the negative results are ignored in this Summary Table.
Target Site Codes:   eso = esophagus. liv = liver. smi = small intestine. sto = stomach. Target sites are listed if any author of published experimental results concluded that tumors were induced in that organ by the test agent. If there is more than one positive experiment in a sex-species, target sites listed may be from more than one experiment, e.g. if liver and lung are both listed, then liver may have been a target in one experiment and lung in another.
TD50: Our standardized measure of carcinogenic potency, TD50, is the daily dose rate in mg/kg body weight/day to induce tumors in half of test animals that would have remained tumor-free at zero dose. Whenever there is more than one positive experiment in a species, the reported TD50 value is a Harmonic Mean calculated using the TD50 value from the most potent target site in each positive experiment.
Superscripts:   m = There is more than one positive experiment in the species, and TD50 values from each positive experiment are used in the calculation of the reported Harmonic mean of TD50.

The Carcinogenic Potency Database (CPDB) is a unique and widely used international resource of the results of 6540 chronic, long-term animal cancer tests on 1547 chemicals. The CPDB provides easy access to the bioassay literature, with qualitative and quantitative analyses of both positive and negative experiments that have been published over the past 50 years in the general literature through 2001 and by the National Cancer Institute/National Toxicology Program through 2004. The CPDB standardizes the diverse literature of cancer bioassays that vary widely in protocol, histopathological examination and nomenclature, and in the published author’s choices of what information to provide in their papers. Results are reported in the CPDB for tests in rats, mice, hamsters, dogs, and nonhuman primates.

For each experiment, information is included on species, strain, and sex of test animal; features of experimental protocol such as route of administration, duration of dosing, dose level(s) in mg/kg body weight/day, and duration of experiment; experimental results are provided on target organ, tumor type, and tumor incidence; carcinogenic potency (TD50) and its statistical significance; shape of the dose-response, author’s opinion as to carcinogenicity, and literature citation.

Only tests with dosing for at least ¼ the standard lifespan of the species and experiment length at least ½ the lifespan are included in the CPDB. Only routes of administration with whole body exposure are included. Doses are standardized, average dose rates in mg/kg/day. A description of methods used in the CPDB to standardize the diverse literature of animal cancer tests is presented for: 1) Criteria for inclusion of experiments 2) Standardization of average daily dose levels and 3) TD50 estimation for a standard lifespan. See Methods for other details.

TD50 provides a standardized quantitative measure that can be used for comparisons and analyses of many issues in carcinogenesis. The range of TD50 values across chemicals that are rodent carcinogens is more than 100 million-fold. More than half the chemicals tested are positive in at least one experiment.

A plot of all results on each experiment in the CPDB for this chemical is presented below. These results are the source information for the Cancer Test Summary table above.

Bis(2,3-dibromopropyl)phosphate, magnesium salt: All Experiments and Citations in CPDB

The definition of each code in the plot below will appear in a pop-up window when the field name in the header line is clicked, e.g., Strain, Site, Path. Each numbered line starts a new experiment and reports protocol information in black. Average daily dose-rates per kg body weight per day are in green. Remaining lines report experimental results in blue.

Abbreviations of fields in header line: # = the line number in the plot of all CPDB chemicals; Xpo = duration of dosing; Xpt = duration of experiment; Site = tissue; Path = tumor type; DR = dose-response; AuOp = author’s opinion about carcinogenicity; LoConf, UpConf = confidence limits (99%) on TD50; Inc = tumor incidence for each dose group.

See Guide to reading the plot for details on each field, using an example of one experiment.

See Help to improve readability, or to fit the plot onto the screen or a printed page.



Chemical (Synonym) CAS
# Species Sex Strain Route Xpo+Xpt PaperNum        0 Dose  1 Dose 2 Dose  3 Dose          Literature Reference or NCI/NTP:Site Path
Site Path Notes   TD50  DR Pval    AuOp LoConf UpConf   Cntrl   1 Inc  2 Inc   3 Inc                                                        Brkly Code



BIS(2,3-DIBROMOPROPYL)PHOSPHATE, MAGNESIUM SALT   36711-31-6
758  R f wis eat 52w52 2102m                         0    4.00mg  20.0mg  100.mg              Takada;japt,11,323-331;1991/pers.comm.
 liv mix ek     11.8mg * P<.0005    4.84mg 36.2mg   0/8     0/8     1/8     7/8
 liv hpa ek     33.2mg * P<.002     11.2mg 185.mg   0/8     0/8     0/8     4/8
 liv hpc ek     35.1mg * P<.009     12.0mg 1.19gm   0/8     0/8     1/8     3/8
 for sqp ek     47.6mg * P<.006     14.2mg 686.mg   0/8     0/8     0/8     3/8
759  R f wis eat 78w78 2102n                         0    4.00mg  20.0mg  100.mg
 liv mix ek     11.9mg * P<.0005    4.87mg 34.9mg   0/8     1/8     3/8     8/8
 for mix ek     19.6mg * P<.0005    7.79mg 58.3mg   0/8     0/8     1/8     8/8
 liv hpc ek     20.1mg * P<.0005    8.06mg 64.1mg   0/8     1/8     0/8     8/8
 for sqp ek     34.5mg * P<.0005    14.0mg 115.mg   0/8     0/8     1/8     6/8
 eso sqp ek     107.mg * P<.006     32.0mg 1.54gm   0/8     0/8     0/8     3/8
 smi adc ek     107.mg * P<.006     32.0mg 1.54gm   0/8     0/8     0/8     3/8
 ton sqp ek     107.mg * P<.006     32.0mg 1.54gm   0/8     0/8     0/8     3/8
 liv hpa ek     20.6mg Z P<.02      6.14mg n.s.s.   0/8     0/8     3/8    (0/8)
 for sqc ek     171.mg * P<.03      41.8mg n.s.s.   0/8     0/8     0/8     2/8
760  R f wis eat 22m23 2102o                         0    4.00mg  20.0mg  100.mg
 liv mix ae     27.8mg * P<.0005 +  14.7mg 65.0mg   1/16    2/16    8/16   14/16
 liv hpc ae     37.1mg * P<.0005 +  20.3mg 74.5mg   0/16    0/16    6/16   13/16
 for mix ae     40.0mg * P<.0005 +  21.7mg 81.6mg   0/16    0/16    5/16   13/16
 for sqp ae     60.3mg * P<.0005 +  31.4mg 134.mg   0/16    0/16    3/16   11/16
 smi adc ae     179.mg * P<.0005 +  72.7mg 644.mg   0/16    0/16    0/16    6/16
 eso sqp ae     394.mg * P<.008  +  119.mg 8.01gm   0/16    0/16    0/16    3/16
 for sqc ae     301.mg * P<.08   +  104.mg n.s.s.   0/16    0/16    2/16    2/16
 ton mix ae     301.mg * P<.08      104.mg n.s.s.   0/16    0/16    2/16    2/16
 ton sqp ae     403.mg * P<.05      122.mg n.s.s.   0/16    0/16    1/16    2/16
 kid mix ae     608.mg * P<.03      149.mg n.s.s.   0/16    0/16    0/16    2/16
 kid rca ae     1.25gm * P<.2       203.mg n.s.s.   0/16    0/16    0/16    1/16
 kid rcc ae     1.25gm * P<.2       203.mg n.s.s.   0/16    0/16    0/16    1/16
 liv hpa ae     no dre   P=1.       189.mg n.s.s.   1/16    2/16    2/16    1/16
 ton sqc ae     no dre   P=1.       227.mg n.s.s.   0/16    0/16    1/16    0/16
761  R m wis eat 52w52 2102m                         0    3.20mg  16.0mg  80.0mg
 for mix ek     38.1mg * P<.006     11.4mg 549.mg   0/8     0/8     0/8     3/8
 smi mix ek     38.1mg * P<.006     11.4mg 549.mg   0/8     0/8     0/8     3/8
 for sqp ek     60.9mg * P<.03      14.9mg n.s.s.   0/8     0/8     0/8     2/8
 smi adc ek     60.9mg * P<.03      14.9mg n.s.s.   0/8     0/8     0/8     2/8
 for sqc ek     129.mg * P<.2       21.0mg n.s.s.   0/8     0/8     0/8     1/8
 kid rcc ek     129.mg * P<.2       21.0mg n.s.s.   0/8     0/8     0/8     1/8
 liv hpc ek     129.mg * P<.2       21.0mg n.s.s.   0/8     0/8     0/8     1/8
 liv mix ek     129.mg * P<.2       21.0mg n.s.s.   0/8     0/8     0/8     1/8
 smi ade ek     129.mg * P<.2       21.0mg n.s.s.   0/8     0/8     0/8     1/8
 eso sqp ek     no dre   P=1.       1.06mg n.s.s.   0/8     0/8     0/8     0/8
 liv hpa ek     no dre   P=1.       1.06mg n.s.s.   0/8     0/8     0/8     0/8
762  R m wis eat 78w78 2102n                         0    3.20mg  16.0mg
 eso sqp ek     16.5mg * P<.02      4.92mg n.s.s.   0/8     0/8     3/8
 liv hpa ek     28.3mg * P<.5       5.00mg n.s.s.   2/8     1/8     3/8
 for sqp ek     56.1mg * P<.2       9.11mg n.s.s.   0/8     0/8     1/8
 kid rca ek     56.1mg * P<.2       9.11mg n.s.s.   0/8     0/8     1/8
 ton sqc ek     56.1mg * P<.2       9.11mg n.s.s.   0/8     0/8     1/8
763  R m wis eat 21m24 2102o                         0    3.20mg  16.0mg  80.0mg
 kid mix ae     35.0mg Z P<.003     13.2mg 178.mg   0/16    0/16    5/16   (0/24)
 for mix ae     37.8mg * P<.0005 +  22.5mg 72.1mg   0/16    0/16    8/16   16/24
 for sqp ae     43.5mg * P<.0005 +  25.5mg 85.9mg   0/16    0/16    7/16   15/24
 kid rca ae     45.1mg Z P<.006     15.5mg 492.mg   0/16    0/16    4/16   (0/24)
 eso mix ae     45.1mg Z P<.006  +  15.5mg 492.mg   0/16    0/16    4/16   (2/24)
 smi adc ae     79.0mg * P<.0005 +  42.0mg 175.mg   0/16    0/16    2/16   12/24
 eso sqp ae     62.1mg Z P<.02   +  18.7mg n.s.s.   0/16    0/16    3/16   (2/24)
 for sqc ae     979.mg * P<.5       178.mg n.s.s.   0/16    0/16    1/16    1/24
 eso sqc ae     no dre   P=1.       274.mg n.s.s.   0/16    0/16    1/16    0/24
 kid rcc ae     no dre   P=1.       274.mg n.s.s.   0/16    0/16    1/16    0/24
 liv hpa ae     no dre   P=1.       236.mg n.s.s.   5/16    2/16    4/16    2/24
 liv hpc ae     no dre   P=1.       245.mg n.s.s.   1/16    2/16    2/16    1/24
 liv mix ae     no dre   P=1.       215.mg n.s.s.   6/16    4/16    6/16    3/24
 ton sqp ae     no dre   P=1.       274.mg n.s.s.   0/16    0/16    1/16    0/24
SMILES Code for Bis(2,3-dibromopropyl)phosphate, magnesium salt: O=P(OCC(CBr)Br)([O-])OCC(CBr)Br.O=P(OCC(CBr)Br)([O-])OCC(CBr)Br.[Mg+2]
InChI Code for Bis(2,3-dibromopropyl)phosphate, magnesium salt: InChI=1/2C6H11Br4O4P.Mg/c2*7-1-5(9)3-13-15(11,12)14-4-6(10)2-8;/h2*5-6H,1-4H2,(H,11,12);/q;;+2/p-2
Source for SMILES and InChI: USEPA Distributed Structure-Searchable Toxicity (DSSTox) Database
Chemical Structure for Bis(2,3-dibromopropyl)phosphate, magnesium salt: Chemical Structure
Source for structure: National Library of Medicine ChemIDPlus

See full CPDB Summary Table on 1547 chemicals. See Full CPDB for all results on 6540 experiments of 1547 chemicals.

A complete list of CPDB chemicals, which is searchable by name or by CAS number, is available here.

For a compendium of CPDB results organized by target organ, which lists all chemicals in each species that induced tumors in each of 35 organs, see Summary Table by Target Organ.

The CPDB is available in several formats that permit printing and downloading into spreadsheets and statistical databases.

  1. A plot of the CPDB presents results of 1547 experiments on 6540 chemicals in an easily readable format that has been used in publications of the CPDB.
  2. A Screen version plot for use on a single computer screen, with the same data.
  3. Excel version of the same data.
  4. Tab-separated versions of the same data, which can be easily read into databases.

A Supplementary Dataset gives details on dosing and survival for each experiment.

Relatively precise estimates of the lower confidence limit on the TD10 (LTD10) are readily calculated from the TD50 and its lower confidence limit, which are reported in the CPDB. For researchers and regulatory agencies interested in LTD10 values, we provide them in an Excel spreadsheet.

PDF versions of our publications of analyses using the CPDB are available, organized by year and by research topic.

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Last updated: October 3, 2007