Nitrite, sodium: Carcinogenic Potency Database

Nitrite, sodium (CAS 7632-00-0)
SMILES, InChI and Structure are below.
Rats and Mice: Cancer Test Summary

Rat Target Sites		Mouse Target Sites		TD₅₀ (mg/kg/day)
Male	Female	Male	Female	Rat	Mouse
hmo(B) liv	hmo(B) liv	no positive	no positive	167^m	no positive

Hamsters: Cancer Test Summary

Hamster Target Sites		TD₅₀ (mg/kg/day)
Male	Female	TD₅₀ (mg/kg/day)
no positive	no positive	no positive

Key to the Table Above

Positivity: For each chemical with a positive (carcinogenic) experiment in the Carcinogenic Potency Database (CPDB), results are included on carcinogenic potency (TD₅₀) in each species and target sites in males and females. Positivity is determined by an author’s opinion in a published paper. If all experimental results in the CDPB are negative in a sex-species group, “no positive” appears. If the CPDB has no experiments in the sex-species group, “no test” appears. The summary presents the strongest evidence of carcinogenicity in each group. If there are both positive and negative experiments in a sex-species, the negative results are ignored in this Summary Table.

Target Site Codes: hmo = hematopoietic system. liv = liver. (B) = experimental results were reported only for both sexes together. Target sites are listed if any author of published experimental results concluded that tumors were induced in that organ by the test agent. If there is more than one positive experiment in a sex-species, target sites listed may be from more than one experiment, e.g. if liver and lung are both listed, then liver may have been a target in one experiment and lung in another.

TD₅₀: Our standardized measure of carcinogenic potency, TD₅₀, is the daily dose rate in mg/kg body weight/day to induce tumors in half of test animals that would have remained tumor-free at zero dose. Whenever there is more than one positive experiment in a species, the reported TD₅₀ value is a Harmonic Mean calculated using the TD₅₀ value from the most potent target site in each positive experiment.

Superscripts: m = There is more than one positive experiment in the species, and TD₅₀ values from each positive experiment are used in the calculation of the reported Harmonic mean of TD₅₀.

The Carcinogenic Potency Database (CPDB) is a unique and widely used international resource of the results of 6540 chronic, long-term animal cancer tests on 1547 chemicals. The CPDB provides easy access to the bioassay literature, with qualitative and quantitative analyses of both positive and negative experiments that have been published over the past 50 years in the general literature through 2001 and by the National Cancer Institute/National Toxicology Program through 2004. The CPDB standardizes the diverse literature of cancer bioassays that vary widely in protocol, histopathological examination and nomenclature, and in the published author’s choices of what information to provide in their papers. Results are reported in the CPDB for tests in rats, mice, hamsters, dogs, and nonhuman primates.

For each experiment, information is included on species, strain, and sex of test animal; features of experimental protocol such as route of administration, duration of dosing, dose level(s) in mg/kg body weight/day, and duration of experiment; experimental results are provided on target organ, tumor type, and tumor incidence; carcinogenic potency (TD₅₀) and its statistical significance; shape of the dose-response, author’s opinion as to carcinogenicity, and literature citation.

Only tests with dosing for at least ¼ the standard lifespan of the species and experiment length at least ½ the lifespan are included in the CPDB. Only routes of administration with whole body exposure are included. Doses are standardized, average dose rates in mg/kg/day. A description of methods used in the CPDB to standardize the diverse literature of animal cancer tests is presented for: 1) Criteria for inclusion of experiments 2) Standardization of average daily dose levels and 3) TD₅₀ estimation for a standard lifespan. See Methods for other details.

TD₅₀ provides a standardized quantitative measure that can be used for comparisons and analyses of many issues in carcinogenesis. The range of TD₅₀ values across chemicals that are rodent carcinogens is more than 100 million-fold. More than half the chemicals tested are positive in at least one experiment.

A plot of all results on each experiment in the CPDB for this chemical is presented below. These results are the source information for the Cancer Test Summary table above.

Nitrite, sodium: All Experiments and Citations in CPDB

The definition of each code in the plot below will appear in a pop-up window when the field name in the header line is clicked, e.g., Strain, Site, Path. Each numbered line starts a new experiment and reports protocol information in black. Average daily dose-rates per kg body weight per day are in green. Remaining lines report experimental results in blue.

Abbreviations of fields in header line: # = the line number in the plot of all CPDB chemicals; Xpo = duration of dosing; Xpt = duration of experiment; Site = tissue; Path = tumor type; DR = dose-response; AuOp = author’s opinion about carcinogenicity; LoConf, UpConf = confidence limits (99%) on TD₅₀; Inc = tumor incidence for each dose group.

See Guide to reading the plot for details on each field, using an example of one experiment.

See Help to improve readability, or to fit the plot onto the screen or a printed page.



Chemical (Synonym) CAS
# Species Sex Strain Route Xpo+Xpt PaperNum        0 Dose  1 Dose 2 Dose  3 Dose          Literature Reference or NCI/NTP:Site Path
Site Path Notes   TD50  DR Pval    AuOp LoConf UpConf   Cntrl   1 Inc  2 Inc   3 Inc                                                        Brkly Code



NITRITE, SODIUM   7632-00-0
4192 H f syg eat 97w97 1831                          0    149.mg                              Ernst;carc,8,1843-1845;1987/pers.comm.
 liv cgf e      no dre   P=1.       402.mg n.s.s.   1/14    0/15
 tba tum e      477.mg   P<.6       78.7mg n.s.s.   5/14    7/15
4193 H m syg eat 24m24 1831                          0    131.mg
 liv tum e      no dre   P=1.       391.mg n.s.s.   0/16    0/15
 tba tum e      no dre   P=1.       134.mg n.s.s.  10/16    6/15
4194 M f b6c wat 24m24 TR495 :                       0    45.0mg  90.0mg  165.mg
 for MXA        1.61gm * P<.06   e  572.mg n.s.s.   1/50    0/50    1/50    5/50                                      for:sqc,sqp.
 TBA MXB        459.mg * P<.4       124.mg n.s.s.  21/50   32/50   31/50   32/50
 liv MXB        no dre   P=1.       553.mg n.s.s.  10/50    8/50    7/50    7/50                                  liv:hpa,hpb,hpc.
 lun MXB        843.mg * P<.2       300.mg n.s.s.   1/50    6/50    5/50    6/50                                      lun:a/a,a/c.
4195 M m b6c wat 24m24 TR495 :                       0    60.0mg  120.mg  220.mg
 TBA MXB        9.19gm * P<1.    -  196.mg n.s.s.  40/50   35/50   36/50   38/50
 liv MXB        no dre   P=1.       324.mg n.s.s.  26/50   25/50   17/50   25/50                                  liv:hpa,hpb,hpc.
 lun MXB        990.mg Z P<.2       316.mg n.s.s.  13/50    6/50   12/50   17/50                                      lun:a/a,a/c.
4196 M f cb6 eat 52w69 1361                          0    489.mg                                         Murthy;ijcn,23,253-259;1979
 liv hpc e      no dre   P=1.    -  532.mg n.s.s.   1/92    0/12
 lun ade e      no dre   P=1.    -  532.mg n.s.s.   2/92    0/12
 tba mix e      no dre   P=1.    -  268.mg n.s.s.  17/92    2/12
4197 M f cb6 wat 27m29 1925                          0    36.8mg  368.mg                             Anderson;canr,45,3561-3566;1985
 lun tum g      5.20gm * P<.5    -  788.mg n.s.s.   1/20    1/15    2/17
 liv mix g      no dre   P=1.    -  1.33gm n.s.s.   3/20    1/15    1/17
4198 M m cb6 eat 52w69 1361                          0    452.mg                                         Murthy;ijcn,23,253-259;1979
 lun ade e      1.61gm   P<.2    -  236.mg n.s.s.   1/95    1/11
 liv hpc e      no dre   P=1.    -  451.mg n.s.s.   2/95    0/11
 tba mix e      1.21gm   P<.4    -  185.mg n.s.s.   8/95    2/11
4199 M f icr wat 25m25 2328                          0    173.mg  244.mg  471.mg                Inai;gann,70,203-208;1979/pers.comm.
 lun tum        7.23gm * P<.5    -  1.71gm n.s.s.   3/20    3/50    2/50    8/50
 liv tum        no dre   P=1.    -  6.27gm n.s.s.   1/20    0/50    0/50    1/50
 tba mix        no dre   P=1.    -  708.mg n.s.s.  10/20   19/50   21/50   22/50
4200 M m icr wat 25m25 2328                          0    241.mg  429.mg  702.mg
 lun tum        16.3gm * P<.7    -  2.29gm n.s.s.   2/20    6/50    4/50    7/50
 liv tum        25.0gm * P<.7    -  5.18gm n.s.s.   0/20    1/50    1/50    1/50
 tba mix        no dre   P=1.    -  1.67gm n.s.s.   9/20   23/50   16/50   18/50
4201 M f scd wat  8m29 1255                          0    30.7mg                                       Anderson;ijcn,24,319-322;1979
 liv hct s      744.mg   P<.7    -  79.3mg n.s.s.   1/16    2/20
 lun tum s      no dre   P=1.    -  132.mg n.s.s.   3/16    1/20
4202 M m scd wat  8m27 1255                          0    27.7mg
 lun tum s      103.mg   P<.3    -  25.7mg n.s.s.   4/21    6/17
 liv hct s      no dre   P=1.    -  52.8mg n.s.s.   5/21    3/17
4203 M f vms wat 31m31 2320                          0    400.mg                                         Hawkes;huet,11,279-281;1992
 bra gli r      no dre   P=1.    -  8.36gm n.s.s.   1/100   1/100
4204 M m vms wat 26m26 2320                          0    333.mg
 bra gli r      no dre   P=1.    -  8.11gm n.s.s.   0/100   0/100
4205 R f f34 wat 24m24 TR495 :                       0    42.9mg  85.7mg  171.mg
 TBA MXB        74.4gm * P<1.    -  108.mg n.s.s.  45/50   45/50   49/50   45/50
 liv MXB        no dre   P=1.       n.s.s. n.s.s.   0/50    0/50    0/50    0/50                                  liv:hpa,hpb,hpc.
4206 R f f34 eat 52w69 1361                          0    188.mg                                         Murthy;ijcn,23,253-259;1979
 liv tum e      no dre   P=1.    -  273.mg n.s.s.   0/44    0/16
 tba mix e      no dre   P=1.    -  88.4mg n.s.s.  20/44    6/16
4207 R f f34 wat 24m28 1490                          0    51.0mg  85.0mg                                  Maekawa;fctx,20,25-33;1982
 liv mix e      no dre   P=1.    -  420.mg n.s.s.   1/49    0/48    0/48
 tba mix e      no dre   P=1.    -  154.mg n.s.s.  45/49   41/48   35/48
4208 R f f34 eat 24m30 1645m                         0    80.0mg                                 Lijinsky;jtxe,13,609-614;1984/1983a
 liv mix e      124.mg   P<.003  +  56.7mg 817.mg   4/24   14/24
 liv nnd e      199.mg   P<.03      78.9mg n.s.s.   4/24   11/24
 liv car e      470.mg   P<.02      162.mg n.s.s.   0/24    4/24
4209 R f f34 eat 24m30 1654m                         0    80.9mg                                 Lijinsky;fctx,22,715-720;1984/1983a
 liv mix e      141.mg   P<.007  +  62.0mg 2.04gm   4/24   13/24
 liv nnd e      164.mg   P<.02      69.2mg n.s.s.   4/24   12/24
 liv hpc e      629.mg   P<.04      190.mg n.s.s.   0/24    3/24
4210 R f f34 wat 24m30 1654n                         0    63.5mg
 adr mdt e      163.mg   P<.0005    73.1mg 523.mg   0/24    8/24
 thy car e      163.mg   P<.0005    73.1mg 523.mg   0/24    8/24
 mam tum e      115.mg   P<.05      44.1mg n.s.s.   8/24   15/24
 liv mix e      153.mg   P<.03   +  60.7mg n.s.s.   4/24   11/24
 liv nnd e      185.mg   P<.06      68.2mg n.s.s.   4/24   10/24
 ute pol e      218.mg   P<.02      85.8mg n.s.s.   1/24    7/24
 liv hpc e      1.55gm   P<.3       252.mg n.s.s.   0/24    1/24
4211 R f f34 eat 24m30 1854                          0    87.9mg                             Lijinsky;txih,3,413-422;1987/pers.comm.
 liv mix        136.mg   P<.003     62.3mg 897.mg   4/24   14/24
 liv nnd        218.mg   P<.03      86.7mg n.s.s.   4/24   11/24
 liv hpc        516.mg   P<.02      178.mg n.s.s.   0/24    4/24
4212 R m f34 wat 24m24 TR495 :                       0    37.5mg  75.0mg  150.mg
 ski fib #      667.mg * P<.04   -  325.mg n.s.s.   0/50    1/50    6/50    3/50                                                   S
 TBA MXB        no dre   P=1.       81.2mg n.s.s.  45/50   39/50   44/50  (37/50)
 liv MXB        6.55gm * P<.7       1.07gm n.s.s.   0/50    0/50    1/50    0/50                                  liv:hpa,hpb,hpc.
4213 R m f34 eat 52w69 1361                          0    151.mg                                         Murthy;ijcn,23,253-259;1979
 liv tum e      no dre   P=1.    -  218.mg n.s.s.   0/50    0/16
 tba mix e      no dre   P=1.    -  58.8mg n.s.s.  30/50    8/16
4214 R m f34 wat 24m28 1490                          0    45.2mg  81.0mg                                  Maekawa;fctx,20,25-33;1982
 liv mix e      1.31gm * P<.5    -  306.mg n.s.s.   4/46    5/49    7/50
 tba mix e      noTD50   P=1.    -  n.s.s. n.s.s.  46/46   49/49   50/50
4215 R m f34 eat 24m30 1645m                         0    64.0mg                                 Lijinsky;jtxe,13,609-614;1984/1983a
 liv mix e      445.mg   P<.3       114.mg n.s.s.   3/24    6/24
 liv nnd e      467.mg   P<.3       125.mg n.s.s.   2/24    5/24
 liv car e      no dre   P=1.       297.mg n.s.s.   1/24    1/24
4216 R m f34 eat 24m30 1654m                         0    64.7mg                                 Lijinsky;fctx,22,715-720;1984/1983a
 liv nnd e      no dre   P=1.       235.mg n.s.s.   5/24    3/24
4217 R m f34 wat 24m30 1654n                         0    44.5mg
 liv mix e      946.mg   P<.7       109.mg n.s.s.   3/24    4/24
 liv hpc e      1.04gm   P<.6       143.mg n.s.s.   1/24    2/24
 liv nnd e      no dre   P=1.       160.mg n.s.s.   2/24    2/24
4218 R m f34 eat 24m30 1854                          0    92.3mg                             Lijinsky;txih,3,413-422;1987/pers.comm.
 liv mix        641.mg   P<.3       164.mg n.s.s.   3/24    6/24
 liv nnd        674.mg   P<.3       180.mg n.s.s.   2/24    5/24
 liv hpc        no dre   P=1.       429.mg n.s.s.   1/24    1/24
4219 R m f34 eat 27m27 1920                          0    80.0mg  200.mg                                  Grant;fctx,27,565-571;1989
 tes ict ef     no dre   P=1.    -  109.mg n.s.s.  16/20   31/48   (7/50)
 --- mnl ef     no dre   P=1.    -  348.mg n.s.s.   9/18    7/39   (3/40)
 mix lym ef     no dre   P=1.    -  371.mg n.s.s.  15/20   14/50  (10/49)
 --- grl ef     no dre   P=1.    -  1.63gm n.s.s.   0/18    1/39    0/40
 tba tum ef     no dre   P=1.    -  389.mg n.s.s.  20/20   45/50   34/50
4220 R b cdr eat 29m29 471                           0    45.0mg                                    Newberne;scie,204,1079-1081;1979
 --- mly        539.mg   P<.03   +  231.mg n.s.s.   6/136  16/136
 spl lym        601.mg   P<.04      246.mg n.s.s.   6/136  15/136
 liv ang        5.84gm   P<.3       952.mg n.s.s.   0/136   1/136
 liv mix        no dre   P=1.       1.08gm n.s.s.   1/136   1/136
4221 R m f3d wat 51w51 2162 ()                       0    100.mg                                           Kawabe;gann,85,17-25;1994
 for tum er     no dre   P=1.    -  74.3mg n.s.s.   0/15    0/15
 stg tum Cer    no dre   P=1.    -  74.3mg n.s.s.   0/15    0/15
4222 R f mrc wat 20m24 213                           0    65.9mg                                     Lijinsky;jnci,50,1061-1063;1973
 tba mix e      57.3mg   P<.03   -  21.4mg n.s.s.   4/15   10/15
4223 R f mrc wat 16m28 1189                          0    11.2mg                                     Greenblatt;jnci,50,799-802;1973
 liv tum e      no dre   P=1.    -  41.3mg n.s.s.   0/20    0/13
 tba tum e      no dre   P=1.    -  6.48mg n.s.s.  14/20    9/13
4224 R m mrc wat 20m24 213                           0    46.2mg                                     Lijinsky;jnci,50,1061-1063;1973
 tba mix e      61.9mg   P<.2    -  18.8mg n.s.s.   5/15    9/15
4225 R m mrc wat 16m28 1189                          0    7.85mg                                     Greenblatt;jnci,50,799-802;1973
 liv tum e      no dre   P=1.    -  33.4mg n.s.s.   0/20    0/15
 tba tum e      no dre   P=1.    -  12.9mg n.s.s.   7/20    4/15
4226 R m wis eat 92w92 1352                          0    32.0mg  64.0mg                                 Aoyagi;jnci,65,411-414;1980
 liv mix e      155.mg * P<.007  +  63.2mg 2.04gm   0/19    1/22    5/19
4227 R m wis wat 24m24 1910m                         0    75.0mg  150.mg               Yamamoto;clet,45,221-225;1989/1996/pers.comm.
 liv tum ej     no dre   P=1.    -  168.mg n.s.s.   0/17    0/17    0/17
4228 R m wis wat 94w94 1914                          0    75.0mg  150.mg                             Yamamoto;carc,10,1607-1611;1989
 liv hpc        no dre   P=1.    -  168.mg n.s.s.   0/20    0/20    0/20
 lun tum        no dre   P=1.    -  168.mg n.s.s.   0/20    0/20    0/20
 nas tum        no dre   P=1.    -  168.mg n.s.s.   0/20    0/20    0/20

Mutagenicity in Salmonella: positive
SMILES Code for Nitrite, sodium: O=N[O-].[Na+]
InChI Code for Nitrite, sodium: InChI=1/HNO2.Na/c2-1-3;/h(H,2,3);/q;+1/p-1
Source for SMILES and InChI: USEPA Distributed Structure-Searchable Toxicity (DSSTox) Database

Chemical Structure for Nitrite, sodium:

Source for structure: National Library of Medicine ChemIDPlus

See full CPDB Summary Table on 1547 chemicals. See Full CPDB for all results on 6540 experiments of 1547 chemicals.

A complete list of CPDB chemicals, which is searchable by name or by CAS number, is available here.

For a compendium of CPDB results organized by target organ, which lists all chemicals in each species that induced tumors in each of 35 organs, see Summary Table by Target Organ.

The CPDB is available in several formats that permit printing and downloading into spreadsheets and statistical databases.

A plot of the CPDB presents results of 1547 experiments on 6540 chemicals in an easily readable format that has been used in publications of the CPDB.
A Screen version plot for use on a single computer screen, with the same data.
Excel version of the same data.
Tab-separated versions of the same data, which can be easily read into databases.

A Supplementary Dataset gives details on dosing and survival for each experiment.

Relatively precise estimates of the lower confidence limit on the TD₁₀ (LTD₁₀) are readily calculated from the TD₅₀ and its lower confidence limit, which are reported in the CPDB. For researchers and regulatory agencies interested in LTD₁₀ values, we provide them in an Excel spreadsheet.

PDF versions of our publications of analyses using the CPDB are available, organized by year and by research topic.

Carcinogenic Potency Database Project (CPDB) Home Page
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Last updated: October 3, 2007